Richmond earned his prizefighter status after he defeated Jack Holmes in 26 rounds at Kilburn. He was most famous for his fight against Tom Cribb, a famous English bare-knuckle boxer. Although Richmond was faster than Cribb, he was beaten in the 60th round of the match. In 1809, he won 100 guineas after beating George Maddox after fighting 52 rounds.
After he retired from boxing, Richmond married a wealthy woman and bought a pub called the Horbill-se and Dolphin with his final winnings of his last fight. He also opened a boxing academy to teach young men his boxing skills.
In 1999, Bill Richmond was inducted into the International Boxing Hall of Fame.